CeCl_3・7H_2O/LiI : A Novel Reagent System for the Synthesis of 4-Iodotetrahydropyrans via Prins Cyclization
Homoallylic alcohols undergo smooth coupling with a variety of aldehydes in the presence of CeCl<SUB>3</SUB>·7H<SUB>2</SUB>O–LiI reagent system in refluxing dichloroethane under neutral conditions to produce the corresponding 4-iodotetrahydropyran derivatives in high yields. The spirocyclic-4-iodotetrahydropyrans are obtained in case of cyclic ketones.
- Chemistry letters
Chemistry letters 36(3), 426-427, 2007-03-05
The Chemical Society of Japan