Relationship between Metabolic Syndrome and Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene in a General Sample : The Shigaraki Study

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著者

    • TAMAKI Shinji
    • Division of Cardiology, Department of Medicine, Kohka Public Hospital
    • TABARA Yasuharu
    • Division of EcoGenetics, Department of Environmental Health and Social Medicine, Ehime University School of Medicine
    • KITA Yoshikuni
    • Department of Health Science, Shiga University of Medical Science
    • TSUJITA Yasuyuki
    • Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
    • HORIE Minoru
    • Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
    • MIKI Tetsuro
    • Department of Geriatric Medicine, Ehime University School of Medicine

抄録

<b>Objective:</b> Simplified sleep polysomnography was performed in 207 adult men to examine the relationship between the frequency of sleep-disordered breathing (SDB) and lifestyle-related illness.<br> <b>Methods:</b> Each subject was checked for SDB using a simplified sleep polysomnograph (Auto-Set Portable; Teijin Limited, Tokyo, Japan). Apnea and hypopnea were detected with a nasal cannula type airflow sensor. Hypoxemia was checked with a percutaneous oxygen saturation (SpO<sub>2</sub>) monitor. We analyzed the relationships between SDB and body mass index (BMI) and hypertension, hyperlipidemia, liver dysfunction, fatty liver, and abnormal glucose metabolism.<br> <b>Results:</b> Fifty-nine subjects (29%) showed SDB with apnea hypopnea index (AHI) over 15 times/h. The frequency of obesity (BMI≥25), hypertension, hypercholesterolemia, fasting blood glucose level, and HbA1c were significantly higher in patients with SDB than in normal individuals (AHI<5 times/h). The frequencies of hypertension, hyperlipidemia, and abnormal glucose metabolism were compared between the obesity-free normal AHI group and the SDB group, and only that of hypertension was significantly different between the two groups.<br> <b>Conclusions:</b> The present study revealed a high frequency of SDB among Japanese individuals. The results also suggest that as SDB becomes severe, it becomes more closely linked to the onset of lifestyle-related illnesses, such as hypertension, hypercholesterolemia and abnormal glucose metabolism.<br>

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension  

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 29(11), 891-896, 2006-11-01 

    The Japanese Society of Internal Medicine

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