Anti-Allergic Phlorotannins from the Edible Brown Alga, Eisenia Arborea

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著者

    • NISHIKAWA Masashi
    • Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University
    • SHIOYA Kazufumi
    • Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University
    • KATSUZAKI Hirotaka
    • Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University
    • IMAI Kunio
    • Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University
    • AMANO Hideomi
    • Laboratory of Marine Biochemistry, Graduate School of Bioresources, Mie University

抄録

<I>Eisenia arborea, </I>an edible brown alga, is occasionally used as a folk medicine due to its anti-allergic effect. In the present study to identify the anti-allergic constituents in the alga, the extract of the alga was purified by partition between solvents and by reversed phase chromatography. Separation of the extract was guided by the inhibitory activity upon β-hexosaminidase release from the rat basophilic leukemia-2H3 cells. HPLC purification afforded six active compounds. Spectral analyses clarified their structures as eckol, 6,6′-bieckol, 6,8′-bieckol, 8,8′-bieckol, phlorofucofuroeckol-A, and phlorofucofuroeckol-B. Most of the phlorotannins exhibited activities similar to or greater than the typical inhibitor, epigallocatechin gallate. Phlorofucofuroeckol-B showed the greatest activity among the tested phlorotannins at 2.8 times greater than epigallocatechin gallate.

収録刊行物

  • Food science and technology research  

    Food science and technology research 13(1), 54-60, 2007-02-01 

    Japanese Society for Food Science and Technology

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各種コード

  • NII論文ID(NAID)
    10018852335
  • NII書誌ID(NCID)
    AA11320122
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13446606
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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