Anti-Allergic Phlorotannins from the Edible Brown Alga, Eisenia Arborea

• SUGIURA Yoshimasa

  Department of Technology, Kanehatsu Food Co., Ltd. Laboratory of Marine Biochemistry, Graduate School of Bioresources, Mie University

• MATSUDA Kohji

  Department of Technology, Kanehatsu Food Co., Ltd.

• YAMADA Yasuhiro

  Department of Technology, Kanehatsu Food Co., Ltd.

• NISHIKAWA Masashi

  Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University

• SHIOYA Kazufumi

  Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University

• KATSUZAKI Hirotaka

  Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University

• IMAI Kunio

  Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University

• AMANO Hideomi

  Laboratory of Marine Biochemistry, Graduate School of Bioresources, Mie University

Bibliographic Information

Other Title

• Anti-allergic phlorotannins from the adible brown alga, Eisenia arborea

Abstract

Eisenia arborea, an edible brown alga, is occasionally used as a folk medicine due to its anti-allergic effect. In the present study to identify the anti-allergic constituents in the alga, the extract of the alga was purified by partition between solvents and by reversed phase chromatography. Separation of the extract was guided by the inhibitory activity upon β-hexosaminidase release from the rat basophilic leukemia-2H3 cells. HPLC purification afforded six active compounds. Spectral analyses clarified their structures as eckol, 6,6′-bieckol, 6,8′-bieckol, 8,8′-bieckol, phlorofucofuroeckol-A, and phlorofucofuroeckol-B. Most of the phlorotannins exhibited activities similar to or greater than the typical inhibitor, epigallocatechin gallate. Phlorofucofuroeckol-B showed the greatest activity among the tested phlorotannins at 2.8 times greater than epigallocatechin gallate.

Journal

• Food Science and Technology Research

  Food Science and Technology Research 13 (1), 54-60, 2007

  Japanese Society for Food Science and Technology

Keywords

• <I>Eisenia arborea</I>
• β-hexosaminidase
• phlorotannin
• RBL-2H3 cell Abbreviations : DSCG : disodium cromoglycate
• EGCg : epigallocatechin gallate
• β-Hex : β-hexosaminidase
• HR-FAB-MS : high resolution FAB-Ms
• PFF : phlorofucofuroeckol
• RBL : rat basophilic leukemia

Details

• CRID: 1390282679432304384
• NII Article ID: 10018852335
• NII Book ID: AA11320122
• DOI: 10.3136/fstr.13.54
• COI: 1:CAS:528:DC%2BD2sXlsFCku78%3D
• ISSN: 18813984
• ISSN: 13446606
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed