Effect of Kokuto, a Non-Centrifugal Cane Sugar, on the Development of Experimental Atherosclerosis in Japanese Quail and Apolipoprotein E Deficient Mice
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<I>Kokuto, </I>a traditional cane sugar of Okinawa, has been reported to have antioxidative and lipid-lowering properties. In this experiment, we investigated the effect of three different kinds of <I>Kokuto </I>(KA, KB, and KC) on atherosclerosis in two different animal models : Japanese quail and apolipoprotein E deficient (apoE-/-) mice. Ingestion of <I>Kokuto </I>had no significant effect on the serum and liver lipid levels of Japanese quail. Dietary intake of atherogenic diet (AD) with KA and KB decreased the liver triglyceride level and body weight in apoE-/- mice. Quail fed on AD with KA developed less extent of lipid-containing aortic intimal thickening lesions than those fed on AD with sucrose. Dietary intake of AD with <I>Kokuto </I>or sucrose induced aortic atheromatous lesions in mice, but the extent of atheromatous lesions was roughly comparable between these dietary groups of apoE-/- mice. The present study suggests that <I>Kokuto </I>prevents lipid-containing aortic intimal thickening lesions in Japanese quail.
- Food Science and Technology International, Tokyo
Food Science and Technology International, Tokyo 13(1), 61-66, 2007-02-01
Japanese Society for Food Science and Technology