骨髄移植後に口腔粘膜にみられた移植後リンパ球増殖症の1例 [in Japanese] A case of post-transplantation lymphoproliferative disorder (PTLD) of the oral mucosa after human bone marrow transplantation [in Japanese]
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A 20-year-old man was referred to our department because of severe pain while eating. Physical examination revealed an erosion and ulcer in the oral cavity. He had been treated for aplastic anemia on an outpatient basis at the Department of Cell Therapy and Transplantation Medicine of our hospital. He had received bone marrow transplants twice. Subsequently, graft-versus-host disease (GVHD) developed, and treatment with cyclosporine was started. Biopsy ruled out the possibility that the lesion in the oral cavity was caused by GVHD. Gingival hyperplasia was noted 8 months later, and granulomatous epulis was diagnosed. The patient's general condition subsequently deteriorated, and mucosal proliferation spread throughout the oral cavity. Biopsy yielded a diagnosis of post-transplantation lymphoproliferative disorder (PTLD). We describe our experience with this rare case of PTLD.
- Journal of Oral Surgery Society of Japan
Journal of Oral Surgery Society of Japan 53(1), 13-17, 2007-01-20
Japanese Society of Oral and Maxillofacial Surgeons