遺伝性血管神経性浮腫患者の抜歯経験 Experience with teeth extractions in a patient who had hereditary angioneurotic edema
Hereditary angioneurotic edema (HANE) is a rare disease caused by functional disorder or reduction of Cl inhibitor. The disease is characterized by episodic localized edema of subcutaneous tissues or gastrointestinal or laryngeal mucosa caused by physical or mental stress. Fatal laryngeal edemamay be caused by dental treatment.<BR>We report the case of a patient with HANE who required teeth extraction.<BR>A female patient had edema of unknown origin of the extremities and face, and abdominal colic since she was in junior high school. In addition, she hadhad laryngeal edema after tooth extraction. Her son also manifested the symptoms. HANE was diagnosed on further examination.<BR>To prevent angioedema, we injected tranexamic acid and a C1 esterase inhibitor before teeth extraction. Treatment was done after endotracheal intubation and tracheostomy. No angioedema was caused by teeth extraction.<BR>Teeth extraction was safely performed in a patient with HANE who was given tranexamic acid and a C1 esterase inhibitor to prevent angioedema.
日本口腔外科学会雑誌 53(1), 38-41, 2007-01-20
Japanese Society of Oral and Maxillofacial Surgeons