先天性第X因子欠乏症患者における抜歯経験 Experience with tooth extraction in a patient who had congenital factor X deficiency
Congenital factor X deficiency is a very rare disease. We present a case of marginal periodontitis in a patient with congenital factor X deficiency. The patient was a 53-year-old woman in whom congenital factor X deficiency was diagnosed on the detection of bloody urine. Our department was consulted by her physician because of swelling of the gingiva around the maxillary right second molar. After administering antibiotic treatment, tooth extraction was performed. The tooth socket was filled with oxidized cellulose, and the gingival defect was primarily closed, achieving good local status. However, continuous oozing from the socket of the tooth increased gradually the next day. Then, the patient was given combined Coagulation Factor Complex (PPSB-HT<SUP>®</SUP>), 1000 units. The factor X activity in serum increased from 7 % to 49 % the day after treatment was initiated. Although the suture was removed on the 7th postoperative day, slight persistent bleeding was observed. Bleeding stopped when thrombin liquid was sprayed over the site of bleeding and pressure was applied with gauze. There was no abnormal hemorrhage, and wound healing was uneventful.
日本口腔外科学会雑誌 52(11), 625-628, 2006-11-20
Japanese Society of Oral and Maxillofacial Surgeons