特発性血小板減少性紫斑病患者の抜歯におけるγ-グロブリン大量療法の検討 Tooth extraction under high-dose gamma-globulin therapy for patients with idiopathic thrombocytopenic purpura

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著者

    • 矢郷 香 YAGO Kaori
    • 慶應義塾大学医学部歯科・口腔外科学教室 Department of Dentistry and Oral Surgery, School of Medicine, Keio University
    • 臼田 慎 USUDA Shin
    • 慶應義塾大学医学部歯科・口腔外科学教室 Department of Dentistry and Oral Surgery, School of Medicine, Keio University
    • 酒向 淳 [他] SAKOH Jun
    • 慶應義塾大学医学部歯科・口腔外科学教室 Department of Dentistry and Oral Surgery, School of Medicine, Keio University
    • 岡田 豊 OKADA Yutaka
    • 慶應義塾大学医学部歯科・口腔外科学教室 Department of Dentistry and Oral Surgery, School of Medicine, Keio University
    • 中川 種昭 NAKAGAWA Taneaki
    • 慶應義塾大学医学部歯科・口腔外科学教室 Department of Dentistry and Oral Surgery, School of Medicine, Keio University

抄録

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by autoantibodies against platelets.<BR>It is necessary for patients with ITP to increase their platelet count before tooth extraction because of an increased risk of bleeding complications.<BR>In 1981 Imbach et al. reported that high-dose gamma-globulin therapy could increase the number of platelets in ITP.<BR>Recently, this treatment has been used clinically in the oral surgical field. However, there are no clinico-statistical reports.<BR>We clinically analyzed 12 patients with ITP who underwent tooth extraction under high-dose gamma-globulin therapy in our hospital from 1989 through 2004.<BR>The results were as follows:<BR>1. In 10 patients (83.3%), the platelet count increased to above 5×104/μ1. In 2 patients (16.7%), there was no elevation of the platelet level.<BR>2. There were no severe side effects associated with therapy.<BR>3. We consider high-dose gamma-globulin therapy very useful for increasing the platelet count immediately before tooth extraction in patients with ITP.

収録刊行物

  • 日本口腔外科学会雑誌  

    日本口腔外科学会雑誌 52(11), 629-633, 2006-11-20 

    Japanese Society of Oral and Maxillofacial Surgeons

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各種コード

  • NII論文ID(NAID)
    10018859094
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00215163
  • NDL 記事登録ID
    8583443
  • NDL 雑誌分類
    ZS44(科学技術--医学--歯科学・口腔外科学)
  • NDL 請求記号
    Z19-145
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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