特発性血小板減少性紫斑病患者の抜歯におけるγ-グロブリン大量療法の検討 Tooth extraction under high-dose gamma-globulin therapy for patients with idiopathic thrombocytopenic purpura
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by autoantibodies against platelets.<BR>It is necessary for patients with ITP to increase their platelet count before tooth extraction because of an increased risk of bleeding complications.<BR>In 1981 Imbach et al. reported that high-dose gamma-globulin therapy could increase the number of platelets in ITP.<BR>Recently, this treatment has been used clinically in the oral surgical field. However, there are no clinico-statistical reports.<BR>We clinically analyzed 12 patients with ITP who underwent tooth extraction under high-dose gamma-globulin therapy in our hospital from 1989 through 2004.<BR>The results were as follows:<BR>1. In 10 patients (83.3%), the platelet count increased to above 5×104/μ1. In 2 patients (16.7%), there was no elevation of the platelet level.<BR>2. There were no severe side effects associated with therapy.<BR>3. We consider high-dose gamma-globulin therapy very useful for increasing the platelet count immediately before tooth extraction in patients with ITP.
日本口腔外科学会雑誌 52(11), 629-633, 2006-11-20
Japanese Society of Oral and Maxillofacial Surgeons