上顎歯肉扁平上皮癌49例の臨床的検討 [in Japanese] A clinicopathological study of 49 patients with squamous cell carcinoma of the upper gingiva [in Japanese]
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A clinicopathological study was made of 49 patients with squamous cell carcinoma of the upper gingiva between 1980 and 2002, and the following findings were obtained.<BR>1) The initial therapy was surgery in 45 patients (34 with an intraoral approach and 11 with an extraoral approach), trimodal combination therapy (external irradiation, per-gingival maxillary sinus surgery, and regional intra-arterial infusion chemotherapy) in 3, and radiotherapy alone in 1. Local cure was obtained in 46 (93.4%) of the 49 patients.<BR>2) Twelve patients (40.8%) had histologically confirmed cervical lymph node metastasis. The most frequent site of metastasis was level II of the neck, especially in patients who had posterior invading cancer.<BR>3) The overall 5-year cumulative survival rate was 74.6%. Three patients died of local failure, 4 of neck failure, 3 of Rouviere lymph node metastasis, and 4 of distant metastasis.<BR>4) Patients with lymph node metastasis in the level II of the neck, contralateralneck metastasis, or Rouviere lymph node metastasis had extremely poor outcomes.<BR>5) Rouviere lymph node metastasis should be taken into consideration in patients who have posterior invading cancer and lymph node metastasis in level II of the neck.
- Journal of Oral Surgery Society of Japan
Journal of Oral Surgery Society of Japan 52(9), 474-479, 2006-09-20
Japanese Society of Oral and Maxillofacial Surgeons