上顎に発生したNK/Tリンパ腫の1例 [in Japanese] A case of NK/T cell lymphoma in the upper jaw [in Japanese]
Access this Article
Search this Article
A 62-year-old man with an NK/T lymphoma originating in the right side of the upper jaw showed destruction of the hard palate and sino-nasal cavity. Intraoral examination revealed an ulcer with necrotic mucosa covering the area from the right side of the upper gingiva to the midline of the palate. CT scanning demonstrated a lesion on the right side of the sino-nasal cavity, and other clinical findings suggested a lethal midline granuloma. A biopsy specimen was positive for CD3, CD56, and Epstein-Barr virus (EBV), but negative for CD20. On the basis of these findings, a definitive diagnosis of NK/T lymphoma was established, and a course of radiation treatment was prescribed. Thereafter, his general condition deteriorated rapidly, and the patient died approximately 4 months later. In this disease, it is very difficult to establish a correct diagnosis. In situ hybridization study for EBV can contribute to the diagnosis because it can detect very small numbers of neoplastic cells in the early stage of disease.
- Journal of Oral Surgery Society of Japan
Journal of Oral Surgery Society of Japan 52(6), 346-349, 2006-06-20
Japanese Society of Oral and Maxillofacial Surgeons