上顎洞粘膜病変における cyclooxygenase-2 発現の検討 Cyclooxygenase-2 expression in maxillary sinus lesions

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著者

    • 岡上 真裕 OKAUE Masahiro
    • 日本大学歯学部口腔外科学教室第1講座 First Department of Oral Maxillofacial Surgery, Nihon University School of Dentistry
    • 鶴田 正 TSURUTA Tadashi
    • 日本大学歯学部口腔外科学教室第2講座 Second Department of Oral Maxillofacial Surgery, Nihon University School of Dentistry
    • 生木 俊輔 NAMAKI Syunsuke
    • 日本大学歯学部口腔外科学教室第2講座 Second Department of Oral Maxillofacial Surgery, Nihon University School of Dentistry
    • 三木 裕香子 MIKI Yukako
    • 日本大学歯学部口腔外科学教室第1講座 First Department of Oral Maxillofacial Surgery, Nihon University School of Dentistry
    • 田中 博 TANAKA Hiroshi
    • 日本大学歯学部口腔外科学教室第1講座 First Department of Oral Maxillofacial Surgery, Nihon University School of Dentistry

抄録

Cyclooxygenases (COXs) are rate-limiting enzymes that initiate the conversion of arachidonic acid to prostanoids. COXs are classified into two isoforms: COX-1 and COX-2. COX-2 is an inducible isoform upregulated by proinflammatory cytokines. Recently, prominent COX-2 expression has been reported in several human cancers, including carcinoma of the colon, breast, lung, head and neck, and gallbladder. Overexpression of COX-2, which is involved in cell proliferation via prostaglandin E<SUB>2</SUB> (PGE2) synthesis, may play a role in tumor progression. In this study, we immunohistochemically characterized COX-2 expression in various diseases of the maxillary sinus, including 5 cases of postoperative maxillary cyst, 5 of maxillary sinusitis, 5 of inverted papilloma, and 5 of maxillary sinus carcinoma. In addition, secretory phospholipase A<SUB>2</SUB>-V, CD3, CD20, and CD68 expression in these lesions was also examined to clarify the relation to COX-2 upregulation. COX-2 was not expressed in the ciliated columnar epithelium in sinusitis, but was expressed in squamous cell metaplasia in maxillary cyst and inverted papilloma. In carcinoma of the maxillary sinus, COX-2 was overexpressed in numerous cancer cells. The proportions of CD3 and CD68 positive cells in carcinoma were clearly lower than those in sinusitis. These results indicated that COX-2 expression correlates with squamous cell metaplasia and epithelial cell proliferation. The end product of the arachidonic acid cascade, PGE<SUB>2</SUB>, may be involved in downregulation of CD3 and CD68 and the proliferation of maxillary sinus carcinoma. Further studies of COX-2 inhibitors as potential antitumor agents in maxillary sinus carcinoma are warranted.

収録刊行物

  • 日本口腔外科学会雑誌  

    日本口腔外科学会雑誌 52(5), 262-270, 2006-05-20 

    Japanese Society of Oral and Maxillofacial Surgeons

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各種コード

  • NII論文ID(NAID)
    10018859855
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00215163
  • NDL 記事登録ID
    7970803
  • NDL 雑誌分類
    ZS44(科学技術--医学--歯科学・口腔外科学)
  • NDL 請求記号
    Z19-145
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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