舌線維腫切除術を行った低コリンエステラーゼ血症の1例 Resection of a tongue fibroma in a patient with serum butyrylcholinesterase deficiency

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著者

    • 西 裕美 NISHI Hiromi
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
    • 東川 晃一郎 HIGASHIKAWA Koichiro
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
    • 小野 重弘 [他] ONO Shigehiro
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
    • 瀧 雅行 TAKI Masayuki
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
    • 井上 伸吾 INOUE Shingo
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
    • 鎌田 伸之 KAMATA Nobuyuki
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University

抄録

Human butyrylcholinesterase (BChE) is an enzyme existing in plasma and liver that dissolves various choline-ester substrates. The serum cholinesterase level indicates the activity of BChE in serum. Low BChE activity is seen in patients with functional disorders of the liver, organic phosphorus exposure and hereditary serum BChE deficiency. In patients with low BChE activity, prolonged neuromuscular block is induced by the use of depolarizing muscle relaxants, such as succinylcholine for general anesthesia, or breathing trouble can be caused by the use of ester-form local anesthetics.<BR>We report a case of tongue fibroma in a 54-year-old man who had extremely low serum BChE activity. While monitoring the circulatory system, the tumor was resected with the use of an amino-form local anesthetic. Hypertension was seen before surgical treatment, possibly due to mental stress, and an antihypertensive was used. DNA sequencing analysis of the BChE gene in this patient revealed a homozygous missense mutation at nucleotide 1093, which resulted in GGA → CGA at Gly365Arg in exon 2.

収録刊行物

  • 日本口腔外科学会雑誌  

    日本口腔外科学会雑誌 52(5), 303-306, 2006-05-20 

    Japanese Society of Oral and Maxillofacial Surgeons

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各種コード

  • NII論文ID(NAID)
    10018860010
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    00215163
  • NDL 記事登録ID
    7970938
  • NDL 雑誌分類
    ZS44(科学技術--医学--歯科学・口腔外科学)
  • NDL 請求記号
    Z19-145
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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