書誌事項
- タイトル別名
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- Protein expression profiling in adenoid cystic carcinoma of the salivary glands
- ダエキセンセン ヨウノウホウガン ニ オケル タンパク ハツゲン プロファイリング
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抄録
To identify specific markers of adenoid cystic carcinoma (ACC), we profiled protein expression in ACC and normal salivary glands (NSGs) by fluorescent 2-dimensional differential in-gel electrophoresis (2-DDIGE), a new technique for comparative proteomics. To identify the proteins, matrix-assisted laser desorption/ionization time-off-flight (MALDI-TOF) peptide mass fingerprinting (PMF) was carried out. Using these strategies, we detected three up-regulated proteins and three down-regulated proteins in ACC. Among these proteins, we obtained two antibodies, which were specific to stathmin and maspin, respectively. With the use of these antibodies, Western blotting confirmed the differential expression of these twoproteins in five clinical samples of ACC tissue, as compared with NSGs. These results may contribute to a better molecular understanding of ACC, as well as to the development of useful clinical biomarkers for tumors.
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 52 (2), 62-68, 2006
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282681510365184
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- NII論文ID
- 10018860370
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 7852790
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可