MRスペクトロスコピーを用いた慢性疼痛患者の評価の試み Proton MR spectroscopy study in chronic pain patients
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We investigated the absolute concentration of N-acetylaspartate (NAA) in the thalamus, anterior cingulated cortex (ACC), and prefrontal cortex (PFC), in chronic pain patients by proton magnetic resonance spectroscopy (<sup>1</sup>H-MRS).<br> <sup>1</sup>H-MRS was performed with a 1.5T MR system on a voxel in the thalamus, ACC, and PFC bilaterally, in 18 chronic pain patients and 15 normal control subjects. We measured the absolute concentration of NAA using a LC-Model.<br> The patients whose NAA concentration in the ACC or PFC decreased significantly, compared to the mean NAA concentration of the normal control subjects, needed psychological approach. <sup>1</sup>H-MRS suggest that NAA concentration in the ACC or PFC seems to be associated with the necessity of psychological approach.<br> <sup>1</sup>H-MRS may serve as a useful non-invasive tool for evaluating neural activity of thalamus, anterior cingulated cortex, and prefrontal cortex in chronic pain patients.
- PAIN RESEARCH
PAIN RESEARCH 22(1), 27-33, 2007-02-26
JAPANESE ASSOCIATION FOR STUDY OF PAIN