経皮治療システム用貼付剤製造装置の開発 [in Japanese] Development of Portable Equipment for Manufacturing Transdermal Patches [in Japanese]
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We have developed Portable Equipment for Manufacturing Transdermal Patch (PEM). This PEM has manufacturing processes, casting membrane of a defined thickness, drying the membrane, covering a backing layer, and cutting the patch, to make a matrix-type devices and runs automatically. Transdermal patches are prepared not only by a conventional solvent-based method but also by a hot-melt method to prevent environment pollution. Quality of the products (thickness, weight, and drug content) by PEM is superior to that by the Film Casting Device with Doctor Blade (FCD). The release profiles from products are proportional to the square root of time, resulting it is an ideal matrix-type patch. The coefficient of variation (CV) of release rate from the products at 6 hrs (1.5%) is less than that from the product on the market (5%). Therefore, PEM is suitable for a teaching, training, and small scale manufacturing in pharmacy colleges and pharmaceutical companies.
MEMBRANE 32(2), 116-119, 2007-03-01
THE MEMBRANE SOCIETY OF JAPAN