Role of α-Galactosylceramide-activated Vα14 Natural Killer T Cells in the Regulation of Allergic Diseases
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- Iwamura Chiaki
- Department of Immunology, Graduate School of Medicine, Chiba University
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- Nakayama Toshinori
- Department of Immunology, Graduate School of Medicine, Chiba University
書誌事項
- タイトル別名
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- Role of .ALPHA.-Galactosylceramide-activated V.ALPHA.14 Natural Killer T Cells in the Regulation of Allergic Diseases
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抄録
Vα14 natural killer T (NKT) cells produce large amounts of both IL-4 and IFN-γ upon stimulation with a ligend, α-galactosylceramide (α-GalCer), and play a crucial role in various immune responses, including allergic reactions. Interestingly, Vα14 NKT cells are not essential for the induction of specific IgE response but they instead tend to induce suppression of specific IgE upon α-GalCer activation in vivo. The suppression in the IgE production is not detected either in Vα14 NKT cell-deficient mice or in IFN-γ-deficient mice. Therefore, activated Vα14 NKT cells are able to exert a potent suppressive activity on Th2 cell differentiation and subsequent IgE production by producing a large amount of IFN-γ. In an OVA-induced asthma model, α-GalCer administration inhibited airway inflammation and airway hyperreactivity by IFN-γ from activated Vα14 NKT cells, thus suggesting the negative regulation of Th2-responses by the activated Vα14 NKT cells.<br>
収録刊行物
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- Allergology International
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Allergology International 56 (1), 1-6, 2007
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390001204631357440
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- NII論文ID
- 10018873574
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- NII書誌ID
- AA11091750
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可