The Relationship between Exhaled Nitric Oxide Measured with an Off-line Method and Airway Reversible Obstruction in Japanese Adults with Asthma

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著者

    • TSUBURAI Takahiro
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • TSURIKISAWA Naomi
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • TANIGUCHI Masami
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • MORITA Sonoko
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • ONO Emiko
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • OSHIKATA Chiyako
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • OHTOMO Mamoru
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • MAEDA Yuji
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • AKIYAMA Kazuo
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital

抄録

<b>Background:</b> Exhaled nitric oxide (eNO) is a useful marker of eosinophilic airway inflammation in asthma patients. There is no study to show the relationship between the eNO measured by using an off-line method and the degree of reversibility of airflow limitation in Japanese asthma patients. We sought to investigate the relationship between the eNO level measured by using an off-line method and the degree of reversibility of bronchial constriction in Japanese asthma patients.<br> <b>Methods:</b> The study population comprised 97 asthma patients in our outpatient clinic with some patients in both groups who received inhaled corticosteroid treatment. We measured eNO levels, forced expiratory volume in one second (FEV<sub>1</sub>) before and after treatment, reversible airway obstruction (ΔFEV<sub>1</sub>) after inhalation of bronchodilator, and other parameters.<br> <b>Results:</b> eNO was significantly correlated with peripheral blood eosinophil counts in asthma patients (in steroid-naïve asthma patients, <i>r</i> = 0.544, <i>p</i> < 0.0001; in asthma patients treated with inhaled corticosteroid, <i>r</i> = 0.463, <i>p</i> = 0.026), and subjects with severe eosinophilia in sputum showed high levels of eNO (mild eosinophilia <i>versus</i> severe, <i>p</i> = 0.0152). Among patients with obstructive impairment, eNO levels were correlated with ΔFEV<sub>1</sub> regardless of whether patients received (<i>r</i> = 0.527, <i>p</i> = 0.0435) or did not receive (<i>r</i> = 0.64, <i>p</i> = 0.0056) inhaled corticosteroid. In subjects with normal pulmonary function, there was no significant relationship between eNO and ΔFEV<sub>1</sub> with or without inhaled corticosteroid.<br> <b>Conclusions:</b> In patients with obstructive impairment, eNO reflects the degree of reversible airflow limitation. In subjects with normal pulmonary function, eNO may facilitate the diagnosis and management of asthma, rather than indicate reversible bronchial obstruction. eNO measurement by off-line methods is applicable as a potential tool for the diagnosis of asthma and management of asthma patients.<br>

収録刊行物

  • Allergology international : official journal of the Japanese Society of Allergology  

    Allergology international : official journal of the Japanese Society of Allergology 56(1), 37-43, 2007-03-01 

    Japanese Society of Allergology

参考文献:  27件

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被引用文献:  8件

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各種コード

  • NII論文ID(NAID)
    10018873784
  • NII書誌ID(NCID)
    AA11091750
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13238930
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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