Radial and Tangential Development of Neurons in the Human Cerebral Cortex-Immunohistochemistory of Ubiquitin Carboxyl Terminal (PGP9.5)-

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  • WATARI Kazuo
    Fukuoka International College of Health and Welfare
  • KAI Satoru
    International University of Health and Welfare Graduate School
  • YOSHIMOTO Ryuji
    Fukuoka International College of Health and Welfare
  • OGAWA Yumi
    Fukuoka International College of Health and Welfare
  • HASE Mayu
    Fukuoka International College of Health and Welfare
  • SEGAWA Yoshie
    Yanagawa Institute for Developmental Disabilities, Child Neurology
  • KANAUMI Takeshi
    Department of Pediatrics, School of Medicine, Fukuoka University
  • TAKASHIMA Sachio
    International University of Health and Welfare Graduate School Yanagawa Institute for Developmental Disabilities, Child Neurology

Bibliographic Information

Other Title
  • ヒト大脳皮質におけるニューロンの放射状および接線状発達―Ｕｂｉｑｕｉｔｉｎ　Ｃａｒｂｏｘｙｌ　Ｔｅｒｍｉｎａｌ　Ｈｙｄｒｏｌａｓｅ（ＰＧＰ９．５）免疫組織化学―
  • ヒト大脳皮質におけるニューロンの放射状および接線状発達--Ubiquitin Carboxyl Terminal Hydrolase (PCP9.5) 免疫組織化学
  • ヒト ダイノウ ヒシツ ニ オケル ニューロン ノ ホウシャジョウ オヨビ セッセンジョウ ハッタツ Ubiquitin Carboxyl Terminal Hydrolase PCP9 5 メンエキ ソシキ カガク
  • -Immunohistochemistory of Ubiquitin Carboxyl Terminal (PGP9.5)-
  • －Ubiquitin Carboxyl Terminal Hydrolase（PGP 9.5）免疫組織化学－

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Abstract

During the developmental period of the cortex, neurocyte cells are produced, differentiated in each area, then move in radial and tangential directions and form a layer structure. We immunohistochemically studied the expression of PGP9.5 (Ubiquitin-carboxyl terminus-enzyme) which was discovered as a unique protein substance in the neurocyte cells of the human cortex during the developmental period. The expression of PGP9.5 during development in humans increased in Cajal-Retzius cells in the external molecular layer at 13 weeks of gestation, then in the fifth layer pyramidal cells, the second and fourth layers granular cells, the third layer pyramidal cells and neurophils in that order, and decreased with advancing age. In cerebral white matter, PGP9.5 was increased in the deep layer around the same time as the molecular layer, then decreased with advancing age. The expression of cells positive for PGP9.5 increases with the healthy development of the human cortex, and it is thought that it reflects the growth and development of neurites and dendrites. Furthermore, from the fact that nerve stem cells develop after damage and show development of neurites and dendrites, they are thought to be an index of regeneration of neurites and dendrites as protein after damage.<br>

Journal

  • Rigakuryoho Kagaku

    Rigakuryoho Kagaku 22 (1), 45-48, 2007

    The Society of Physical Therapy Science

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