A Third Photoreceptor-Specific GRK Found in the Retina of Oryzias latipes (Japanese killifish)

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We previously reported that the teleost fish medaka (Oryzias latipes, Japanese killifish), possesses two kinds of G protein-coupled receptor kinases (GRKs) in the retina with different localizations: GRK7 (OlGRK-C) in cones and GRK1 (OlGRK-R1) in rods. To further clarify the diversity of teleost photoreceptor GRKs, we sought other medaka GRKs. We found an additional cDNA that encodes a second retina-specific GRK1 (OlGRK-R2). In situ hybridization experiments demonstrated that OlGRK-R2 mRNA is selectively expressed in rods. Sequence analysis of the Fugu rubripes genomic database unveiled a larger diversity of GRKs than previously expected. We also describe the light-dependent regulation of GRK1, a phenomenon that has not been found in other species. Immunocytochemical analysis indicated that OlGRK-R2 is localized in rod outer segments, independent of light condition. OlGRK-R1 is localized in the rod inner segments and synaptic termini of dark-adapted eyes, and moves to rod outer segments after light adaptation. Our studies suggest that the two medaka GRKs are not functionally redundant, and demonstrate a complicated light-dependent regulation of GRK1 in vivo.

収録刊行物

  • Zoological science  

    Zoological science 24(1), 87-93, 2007-01-25 

    社団法人 日本動物学会

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各種コード

  • NII論文ID(NAID)
    10018878139
  • NII書誌ID(NCID)
    AA10545874
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    02890003
  • NDL 記事登録ID
    8690562
  • NDL 雑誌分類
    ZR4(科学技術--生物学--動物)
  • NDL 請求記号
    Z53-Y164
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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