Expression of DMRT Genes in the Gonads of Rana rugosa During Sex Determination

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Sex is determined by various transcription factors. Dmrt1, a gene that contains the DM domain (Doublesex/Mab-3 DNA-binding motif), is known to be one of the critical factors required for testicular development in vertebrates. Recently, other DM domain-containing genes (DMRT genes) were isolated in mice and fish. In mice, three of the seven known DMRT genes are expressed in the embryonic gonad. In amphibians, however, only Dmrt1 and Dmrt4 have been cloned. To clarify the role(s) of DMRT genes in sex determination in vertebrates, the molecular cloning of amphibian DMRT genes would be very helpful. In this study, we isolated Dmrt2, -3, and -5 from the frog Rana rugosa and analyzed by RT-PCR their expression during sex determination. The analysis revealed that all three genes are expressed in the developing gonad/mesonephros complex during sex determination with no dimorphism. The results suggest that Dmrt2, -3, and -5 may be involved in sexual development in R. rugosa and that they may function in both testicular and ovarian differentiation.

収録刊行物

  • Zoological science  

    Zoological science 24(1), 95-99, 2007-01-25 

    社団法人 日本動物学会

参考文献:  24件

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各種コード

  • NII論文ID(NAID)
    10018878177
  • NII書誌ID(NCID)
    AA10545874
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    02890003
  • NDL 記事登録ID
    8690566
  • NDL 雑誌分類
    ZR4(科学技術--生物学--動物)
  • NDL 請求記号
    Z53-Y164
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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