Expression of matrix metalloproteinase genes in regressing or remodeling organs during amphibian metamorphosis

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Several matrix metalloproteinases (MMP) are induced by thyroid hormone (TH) during the climax of amphibian metamorphosis, and play a pivotal role in the remodeling intestine and the regressing tail and gills by degrading the extracellular matrix (ECM). We compared MMP gene expression levels precisely by the quantitative real time reverse transcription-polymerase chain reaction. The expression of MMP genes increases prominently at NF stages 60, 60-61, and 62 in the intestine, gills, and tail, respectively, when the drastic morphological change starts in each organ. The gene expression analysis in the TH-treated tadpoles and cell line revealed that MMP mRNAs are up-regulated in response to TH quickly within several hours to low levels and then increase in a day to high levels. All TH-induced MMP genes have thyroid hormone response elements (TREs). The presence of high affinity TREs in MMP genes correlates with the early TH-induction. Based on these results, we propose that TH stimulates the transcription of MMP genes through TREs within several hours to low levels, and then bring about the main increase of mRNAs by TH-induced transcriptional factors including TH receptor β in cell type-specific transcriptional environment.

収録刊行物

  • Development, growth & differentiation  

    Development, growth & differentiation 49(2), 131-143, 2007-03-01 

    Japanese Society of Developmental Biologists

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各種コード

  • NII論文ID(NAID)
    10018878564
  • NII書誌ID(NCID)
    AA00627804
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00121592
  • NDL 記事登録ID
    8689556
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z53-S117
  • データ提供元
    CJP書誌  CJP引用  NDL  IR 
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