Facile Synthesis of 6-Trichloromethylpterin and 2-Chloro-3-trichloromethylquinoxaline along with a Library of Trichloromethyl Heterocycles Using N-Chlorosuccinimide and Triphenyl Phosphine
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A general synthesis of 6-trichloromethylpterin, 2-chloro-3-trichloromethylquinoxaline and 2-amino-7-trichloromethyl-1,8-naphthyridine along with a series of trichloromethyl heterocycles (<B>1</B>–<B>11</B>) has been reported in one-pot mild neutral condition in good yield. This method is compared with the usual method using phosphorus pentachloride in phosphorus oxychloride.
- Chemistry Letters
Chemistry Letters 36(4), 552-553, 2007-04-05
The Chemical Society of Japan