False positive PIVKA-II in patients with hepatocellular carcinoma after hepatectomy

• Sato Makoto

  Department of Central Laboratory, Okayama Saiseikai General Hospital

• Kimura Yasuharu

  Department of Central Laboratory, Okayama Saiseikai General Hospital

• Hagane Masami

  Department of Central Laboratory, Okayama Saiseikai General Hospital

• Fujiwara Nobuko

  Department of Central Laboratory, Okayama Saiseikai General Hospital

• Yamamoto Kazuhide

  Department of Internal Medicine, Okayama Saiseikai General Hospital

• Ohsawa Toshiya

  Department of Internal Medicine, Okayama Saiseikai General Hospital

• Fujioka Shin-ichi

  Department of Internal Medicine, Okayama Saiseikai General Hospital

• Takagi Toshiyuki

  Department of Internal Medicine, Okayama Saiseikai General Hospital

• Itoshima Tatsuya

  Department of Internal Medicine, Okayama Saiseikai General Hospital

• Mimura Tetsushige

  Department of Surgery, Okayama Saiseikai General Hospital

• Niguma Takefumi

  Department of Surgery, Okayama Saiseikai General Hospital

• Egawa Takanori

  Fuhirebio Inc.

• Uehara Masato

  Sanko Junyaku Co., Ltd.

Bibliographic Information

Other Title

• 肝切除術後に生じたＰＩＶＫＡ‐ＩＩ高値現象に関する検討

Abstract

PIVKA-II, an abnormal prothrombin induced by vitamin K deficiency, is widely used as a specific marker for hepatocellular carcinoma. We observed a marked elevation of PIVKA-II in the serum from 12 patients with hepatocellular carcinoma just after hepatectomy, when we determined PIVKA-II by CLEIA (431-23,968mAU/ml). However, 10 of the 12 patients showed normal levels of PIVKA-II when re-tested by ECLIA (1-21mAU/ml). The false positive results with CLEIA were thought to be associated with the use of anti-bleeding sheets at hepatectomy.<br>

Journal

• Kanzo

  Kanzo 48 (3), 115-116, 2007

  The Japan Society of Hepatology

Keywords

• PIVKA-II
• chemiluminescence enzyme immunoassay (CLEIA)
• anti-bleeding sheet

Details

• CRID: 1390282679766849152
• NII Article ID: 10018885269
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.48.115
• ISSN: 18813593
• ISSN: 04514203
• Web Site: http://www.jstage.jst.go.jp/article/kanzo/48/3/48_3_115/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007181374
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed