著明な好酸球増加症をともなった胃食道逆流症の1例 A case of gastroesophageal reflux disease with marked eosinophilia

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73歳女性.主訴は咽頭痛,夜間咳嗽.18000/mm<sup>3</sup>(WBC 21900/mm<sup>3</sup>, Eos 82%)と著明な好酸球増加症および胃食道逆流症と診断した.ランソプラゾール投与により食道炎は軽快,好酸球は正常化した.ファモチジンへの変更にて胸やけの出現と好酸球の増加傾向を認め,オメプラゾールへの変更にて症状は軽快,好酸球も減少した.以上より胃食道逆流症が好酸球増加症の原因の1つとなりうることが示唆された.<br>

A 73-year-old woman without a history of allergic diseases visited our hospital complaining of sore throat and nocturnal cough. Blood tests showed marked eosinophilia (18000/mm<sup>3</sup>;WBC 21900/mm<sup>3</sup>, Eos 82.0%) with normal serum levels of C-reactive protein, non-specific and various allergen-specific IgE. Stool tests for protozoa or helminthic ova were negative. Chest X-ray films showed no pulmonary abnormalities. Endoscopic and histological examinations revealed reflux esophagitis (grade C according to the Los Angeles Classification System) with hiatal hernia with inflammatory infiltrates including eosinophils within the esophageal mucosa. A computed tomography showed the thickening of the esophageal wall. An administration of lansoprazole improved reflux esophagitis and also eosinophilia, and an alteration to famotidine caused heartburn with an increase in eosinophils. A re-alteration to omeprazole relieved the symptom and decreased eosinophils. It was shown that gastroesophageal reflux disease was one of the possible causes of eosinophilia.<br>

収録刊行物

  • 日本消化器病學會雜誌 = The Japanese journal of gastro-enterology  

    日本消化器病學會雜誌 = The Japanese journal of gastro-enterology 104(4), 542-547, 2007-04-05 

    The Japanese Society of Gastroenterology

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各種コード

  • NII論文ID(NAID)
    10018886154
  • NII書誌ID(NCID)
    AN00192124
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    04466586
  • データ提供元
    CJP書誌  J-STAGE 
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