人工肝補助療法を施行し救命し得た genotype IV のE型劇症肝炎の1例 A case of fulminant hepatitis E treated with artificial liver support

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症例は40歳男性.全身倦怠感,褐色尿が出現し,肝障害を認め入院.プロトロンビン時間の著明な低下,肝性昏睡II度を認め,E型肝炎ウイルス抗体高値にてE型劇症肝炎と診断した.保存血清より中国型genotype IV型のE型肝炎ウイルスが検出された.これまで海外にて感染し帰国後劇症化したE型肝炎の報告例はない.経過より脳症発症前から積極的に人工肝補助療法を導入し救命し得たと考えられ,貴重な症例であり報告した.<br>

A 40-year-old man, who had suffered from general malaise and brown urine during his stay in China, was addmitted with remarkable jaundice and hepatocellular disorders soon after he returned to Japan. Because his coagulation test results worsened, he was transferred to our hospital. No evidence of hepatitis A-D virus infection, autoimmune hepatitis, or metabolic disorders was noticed. His prothrombin time was extended (18%), grade II encephalopathy appeared on the second hospital day, and fulminant hepatitis was diagnosed. Artificial liver support was introduced, and his hepatic coma and coagulation parameters gradually recovered. Genotype IV hepatitis E virus RNA was detected in his early phase sera and also both IgG and IgM type anti-hepatitis E virus antibodies were detected. Fulminant hepatitis E resulting from infection in China was diagnosed.<br>

収録刊行物

  • 日本消化器病學會雜誌 = The Japanese journal of gastro-enterology  

    日本消化器病學會雜誌 = The Japanese journal of gastro-enterology 104(2), 219-225, 2007-02-05 

    The Japanese Society of Gastroenterology

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各種コード

  • NII論文ID(NAID)
    10018886635
  • NII書誌ID(NCID)
    AN00192124
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    04466586
  • データ提供元
    CJP書誌  J-STAGE 
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