CEA, CA19-9高値を呈し, 多発性肝転移を認めた食道表在癌の1例 A case of submucosal esophageal carcinoma with multiple liver metastasis showing high serum levels of CEA and CA19-9

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著者

    • 栗原 利和 KURIHARA Toshikazu
    • 財団法人東京都保健医療公社荏原病院内科 Department of Internal Medicine, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital
    • 石井 成明 ISHII Shigeaki
    • 財団法人東京都保健医療公社荏原病院内科 Department of Internal Medicine, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital
    • 小澤 達雄 OZAWA Tatsuo
    • 財団法人東京都保健医療公社荏原病院内科 Department of Internal Medicine, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital
    • 津保 勝郎 TSUBO Katsurou
    • 財団法人東京都保健医療公社荏原病院内科 Department of Internal Medicine, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital
    • 福島 淑隆 FUKUSHIMA Yoshitaka
    • 財団法人東京都保健医療公社荏原病院内科 Department of Internal Medicine, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital
    • 舩冨 等 FUNATOMI Hitoshi
    • 財団法人東京都保健医療公社荏原病院内科 Department of Internal Medicine, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital
    • 加賀谷 寿孝 KAGAYA Toshitaka
    • 財団法人東京都保健医療公社荏原病院内科 Department of Internal Medicine, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital
    • 大池 信之 OHIKE Nobuyuki
    • 財団法人東京都保健医療公社荏原病院病理検査科 Department of Pathology, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital
    • 高橋 学 TAKAHASHI Manabu
    • 財団法人東京都保健医療公社荏原病院病理検査科 Department of Pathology, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital

抄録

症例は57歳,男性.拡張型心筋症にて外来管理中に腹部膨満感が出現し,腹部超音波検査によりびまん性肝腫瘍を認めた.血液検査でCEAとCA19-9の異常高値を認めた.上部消化管内視鏡検査にて中下部食道にヨード不染帯を認め,肉眼型は表在平坦型を呈し病理組織学的に低分化扁平上皮癌と診断され,また,肝腫瘍生検にて転移性食道扁平上皮癌と診断された.全身状態悪化により第41病日永眠された.病理解剖では,癌は粘膜下層まで浸潤し,食道および肝の免疫染色でCEA, CA19-9の発現が認められた.多発性転移をきたした食道表在癌はまれと考え報告した.本例ではCEA, CA19-9 高値であり,生物学的悪性度との関連が示唆された.<br>

A 57-year-old man was admitted because of abdominal fullness. An abdominal ultrasonographic study disclosed multiple space-occupying lesions (SOL) in the liver. On blood examinationC the serum levels of CEA and CA19-9 were significantly highC while those of AFP and SCC were within normal ranges. Endoscopically biopsied specimens of the lower esophagus histologically revealed poorly differentiated squamous cell carcinoma. Pathohistologically similar findings were obtained from the needle biopsied specimen of the SOL in the liver. Thus the patient was diagnosed as having squamous cell carcinoma of the esophagus with liver metastasis. On the 41st hospital dayC the patient died and an autopsy was performed. Although multiple metastases were recognized, cancer cells were limited within the submucosa of the esophagus. Immunostaining of CEA and CA19-9 was positive on the carcinoma cells both in the esophagus and the liver. Thus a relation between the biological malignancy of esophageal cancer and serum levels of CEA and CA19-9 was suggested.<br>

収録刊行物

  • 日本消化器病學會雜誌 = The Japanese journal of gastro-enterology  

    日本消化器病學會雜誌 = The Japanese journal of gastro-enterology 104(1), 23-29, 2007-01-05 

    The Japanese Society of Gastroenterology

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各種コード

  • NII論文ID(NAID)
    10018886821
  • NII書誌ID(NCID)
    AN00192124
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    04466586
  • データ提供元
    CJP書誌  J-STAGE 
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