Effect of tube feeding on hippocampal-dependent memory in SAMP1 mice

• Nishida Yoshie

  Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry

• Iinuma Mitsuo

  Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry

• Tamura Yasuo

  Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry

• Kubo Kin-ya

  Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry

• Iwaku Fumihiko

  Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry

Abstract

This study examined the effect of tube feeding on hippocampal Fos induction and spatial performance in a water maze task in senescence-accelerated mice (SAMP1). Tube feeding accelerated the age-related decline in spatial memory and decreased Fos induction in the hippocampal CA1 region in aged SAMP1 mice. The results suggest that tube feeding in aged SAMP1 mice reduces input activity in the hippocampus, thereby leading to senile memory deficits.

Journal

• Pediatric Dental Journal

  Pediatric Dental Journal 17 (1), 47-52, 2007

  The Japanese Society of Pediatric Dentistry

Keywords

• Fos
• Hippocampus
• SAMP1
• Spatial memory
• Tube feeding

Details

• CRID: 1390282679360799488
• NII Article ID: 130004475816
• NII Article ID: 10018904480
• NII Book ID: AA10809637
• DOI: 10.11411/pdj.17.47
• ISSN: 18803997
• ISSN: 09172394
• Web Site: https://search.jamas.or.jp/link/ui/2008016324
• Text Lang: en
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed