固形癌の Side Population 細胞における遺伝子発現 Gene Expression Pattern of Side Population Cells in Solid Cancers

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著者

    • 松村 耕治 MATSUMURA Kouji
    • 防衛医科大学校共同利用研究施設 Laboratory for Cell Analysis, Central Research Institute, National Defense Medical College
    • 佐々木 功典 SASAKI Kohsuke
    • 山口大学医学部先端分子応用医科学講座分子病理部 Department of Pathology, Yamaguchi University School of Medicine
    • 松山 重雄 MATSUYAMA Shigeo
    • 防衛医科大学校共同利用研究施設 Laboratory for Cell Analysis, Central Research Institute, National Defense Medical College

抄録

<p>Presence of cancer stem cell (CSC) was demonstrated in some kinds of cancer tissues and cell lines. A cancer recurrence is considered with intervention of CSC resistant to anti-cancer drug and understanding of CSC characteristics leads to development of an effective therapy. We reviewed the results of genome-wide gene expression analysis of side population (SP) cells of solid cancers, especially from a head and neck origin,for the purpose of a search of candidate gene marker(s) of cancer stem cells. SP cells, enriched with stem cells, were observed in head and neck cancer cell lines. The genes which most strongly varied in expression between SP cell /Non-SP cells were neurogenetic, cutaneous disease relations and ATP-binding cassette,sub-family G, member 2 (ABCG2), was overexpressed at the highest level. The genes showed expression profiles similar to ABCG2 were cancerous testiculus antigen and several transcription factors. Annexin family genes showed reverse to ABCG2 expression patterns. The genes, those whom included in cancer SP cells,not in normal cells in particular, were categories of inhibit cell growth, metabolism, and biosynthesis, and are candidate gene markers of an effective treatment with anti-cancer drug. Microarray screened genes are analyzed in detail, and it is necessary to clarify characteristics of cancer stem cells in future.</p>

収録刊行物

  • Cytometry research = 日本サイトメトリー学会機関誌

    Cytometry research = 日本サイトメトリー学会機関誌 17(1), 29-34, 2007-03-25

    日本サイトメトリー学会

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