病態解析におけるサスペンションアレイ法(CBA法)の有用性 ; 関節リウマチの病態解析における応用例 Validity of Suspension-Array Analysis for Prognosis of Rheumatoid Arthritis

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<p>Rheumatoid Arthritis (RA) is one of the common autoimmune disease and remarkably decline patient's quality of life (QOL) by destruction of the joint when the disease progress and became untreatable. To arrest progression of the disease, rapid and precise diagnosis becomes an important matter. We use suspension-array analysis to find out candidate factors, those foresight the fate of the disease. Interestingly, peripheral CD4+CD25bright regulatory T cell subset, which plays an important role to suppress inflammatory reactions,were identical between normal control and severe RA patients. However suspension-array analysis on 17 cytokines revealed decreased production of IL-10 and elevated production of IFN-γ. Our findings suggest the possibility that the abrogation of regulatory T cell function deteriorate pathogenesis of rheumatoid arthritis.</p>

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  • Cytometry research = 日本サイトメトリー学会機関誌

    Cytometry research = 日本サイトメトリー学会機関誌 17(1), 43-49, 2007-03-25

    日本サイトメトリー学会

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