Validity of Suspension-Array Analysis for Prognosis of Rheumatoid Arthritis

• Kashiwamura Shin-Ichiro

  Laboratory of Host Defenses, Institute for Advanced Medical Sciences, Hyogo College of Medicine

Bibliographic Information

Other Title

• <b>病態解析におけるサスペンションアレイ法（</b><b>CBA</b><b>法）の有用性； 関節リウマチの病態解析における</b><b>応用例 </b>

Abstract

Rheumatoid Arthritis (RA) is one of the common autoimmune disease and remarkably decline patient's quality of life (QOL) by destruction of the joint when the disease progress and became untreatable. To arrest progression of the disease, rapid and precise diagnosis becomes an important matter. We use suspension-array analysis to find out candidate factors, those foresight the fate of the disease. Interestingly, peripheral CD4+CD25bright regulatory T cell subset, which plays an important role to suppress inflammatory reactions,were identical between normal control and severe RA patients. However suspension-array analysis on 17 cytokines revealed decreased production of IL-10 and elevated production of IFN-γ. Our findings suggest the possibility that the abrogation of regulatory T cell function deteriorate pathogenesis of rheumatoid arthritis.

Journal

• Cytometry Research

  Cytometry Research 17 (1), 43-49, 2007

  Japan Cytometry Society

Keywords

• Rheumatoid Arthritis
• Suspension-array
• Cytokine
• Inflammation
• Regulatory T cell

Details

• CRID: 1390001204472354688
• NII Article ID: 10018906951
• NII Book ID: AN10356261
• DOI: 10.18947/cytometryresearch.17.1_43
• ISSN: 24240664
• ISSN: 09166920
• Web Site: https://search.jamas.or.jp/link/ui/2007235283
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed