Complications in the central nervous system during chemotherapy for childhood acute lymphoblastic leukemia: JACLS ALL-02 study

• UMEDA Katsutsugu

  Department of Pediatrics, Kyoto University

• YOSHIDA Makoto

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• SUZUKI Nobuhiro

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• ENDO Mikiya

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• SATO Atsushi

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• HORI Hiroki

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• ISOGAI Mitsuharu

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• MATSUMOTO Kimikazu

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• HARA Jun-ichi

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• HASEGAWA Daiichiro

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• HASHII Yoshiko

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• CHAYAMA Kosuke

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• MIYAJI Ryousuke

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• NISHIMURA Shin-ichiro

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• TANIZAWA Akihiko

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• USAMI Ikuya

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• HORIBE Keizo

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

• WAKAZONO Yoshihiro

  Department of Pediatrics, Kyoto-Katsura Hospital

• YAGI Keiko

  ALL Committee of the Japan Association of Childhood Leukemia Study (JACLS)

Bibliographic Information

Other Title

• 小児急性リンパ性白血病治療における中枢神経系合併症：JACLS ALL-02研究
• 臨床研究 小児急性リンパ性白血病治療における中枢神経系合併症--JACLS ALL-02研究
• リンショウ ケンキュウ ショウニ キュウセイ リンパセイ ハッケツビョウ チリョウ ニ オケル チュウスウ シンケイケイ ガッペイショウ JACLS ALL 02 ケンキュウ

Abstract

We evaluated central nervous system (CNS) complications treated under the ALL-02 protocol of the Japan Association of Childhood Leukemia Study (JACLS) from April 2002 to March 2005. According to NCI Toxicity Criteria, 17 events of grade 3 and 4 CNS complications were reported in 15 out of 541 patients. Out of these CNS complications, leukoencephalopathy was seen in 5 patients; seizure in 5; cerebrovascular disease in 3; conscious disturbance in 2; and hypertensive encephalopathy and reversible posterior leukoencephalopathy syndrome in one patient each. The complications were intensively observed during induction therapy and the last of the early phase chemotherapy. The protocol treatment was stopped or modified in most patients after CNS complications. MRI imaging demonstrated no improvement in one patient with leukoencephalopathy who developed an isolated CNS relapse, while other patients were alive and remain in their first complete remission without any neurological sequelae. Further studies will be required to analyze risk factors for CNS complications during chemotherapy not accompanied by irradiation and to establish alternative treatments after the appearance of such CNS complications.

Journal

• Rinsho Ketsueki

  Rinsho Ketsueki 48 (3), 204-211, 2007

  The Japanese Society of Hematology

Keywords

• Acute lymphoblastic leukemia
• Central nervous system complication
• Leukoencephalopathy
• Methotrexate

Details

• CRID: 1390282680010214528
• NII Article ID: 10018910092
• NII Book ID: AN00252940
• DOI: 10.11406/rinketsu.48.204
• COI: 1:STN:280:DC%2BD2s3jtlaksg%3D%3D
• ISSN: 18820824
• ISSN: 04851439
• NDL BIB ID: 8778188
• PubMed: 17441477
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8778188
• Web Site: https://search.jamas.or.jp/link/ui/2007253521
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed