C型慢性肝疾患における亜鉛代謝 Clinical Significance of Zinc Metabolism in C-viral Chronic Liver disease

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著者

    • 森山 光彦 MORIYAMA Mitsuhiko
    • 日本大学医学部内科学講座消化器肝臓内科部門 Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
    • 松村 寛 MATSUMURA Hiroshi
    • 日本大学医学部内科学講座消化器肝臓内科部門 Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
    • 田中 直英 [他] TANAKA Naohide
    • 日本大学医学部内科学講座消化器肝臓内科部門 Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
    • 荒川 泰行 ARAKAWA Yasuyuki
    • 日本大学医学部内科学講座消化器肝臓内科部門 Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine

抄録

We evaluated zinc concentrations in patients with hepatitis C virus (HCV)-positive chronic liver disease and correlated them with the clinical profiles of the patients. 11 healthy subjects also were included in this study. Serum zinc concentrations were evaluated using conventional atomic absorption spectrometry. The median concentration of zinc in patients with CH was statistically lower than that in healthy control subjects. The median zinc concentrations of the LC and HCC groups were significantly lower than that of the CH group. A significant correlation was observed between the zinc concentrations and the platelet counts and albumin concentrations. The zinc concentrations did not correlate with tumor size and number and decreased with the development of Child-Pugh stage. The zinc concentrations did not correlate with tumor size and number and decreased with the development of Child-Pugh stage. The cumulative survival rate after therapy for HCC nodules in the low zinc concentration group was significantly lower than in the high group.We concluded the serum concentration of zinc influenced the clinical profiles in patients with C-viral chronic liver disease.

収録刊行物

  • Biomedical research on trace elements  

    Biomedical research on trace elements 18(1), 20-25, 2007-03-31 

    Japan Society for Biomedical Research on Trace Elements

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各種コード

  • NII論文ID(NAID)
    10018910850
  • NII書誌ID(NCID)
    AN10423256
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    0916717X
  • NDL 記事登録ID
    8769272
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z19-3255
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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