Clinical Significance of Zinc Metabolism in C-viral Chronic Liver disease
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- Moriyama Mitsuhiko
- Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
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- Matsumura Hiroshi
- Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
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- Tanaka Naohide
- Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
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- Arakawa Yasuyuki
- Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
Bibliographic Information
- Other Title
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- C型慢性肝疾患における亜鉛代謝
- Cガタ マンセイ カン シッカン ニ オケル アエン タイシャ
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Abstract
We evaluated zinc concentrations in patients with hepatitis C virus (HCV)-positive chronic liver disease and correlated them with the clinical profiles of the patients. 11 healthy subjects also were included in this study. Serum zinc concentrations were evaluated using conventional atomic absorption spectrometry. The median concentration of zinc in patients with CH was statistically lower than that in healthy control subjects. The median zinc concentrations of the LC and HCC groups were significantly lower than that of the CH group. A significant correlation was observed between the zinc concentrations and the platelet counts and albumin concentrations. The zinc concentrations did not correlate with tumor size and number and decreased with the development of Child-Pugh stage. The zinc concentrations did not correlate with tumor size and number and decreased with the development of Child-Pugh stage. The cumulative survival rate after therapy for HCC nodules in the low zinc concentration group was significantly lower than in the high group.We concluded the serum concentration of zinc influenced the clinical profiles in patients with C-viral chronic liver disease.
Journal
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- Biomedical Research on Trace Elements
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Biomedical Research on Trace Elements 18 (1), 20-25, 2007
Japan Society for Biomedical Research on Trace Elements
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Keywords
Details 詳細情報について
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- CRID
- 1390282679343697280
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- NII Article ID
- 10018910850
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- NII Book ID
- AN10423256
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- ISSN
- 18801404
- 0916717X
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- NDL BIB ID
- 8769272
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed