金投与後のラット腎臓内のDNA損傷のメカニズム Mechanisms of the DNA Damage in Rat Kidney after Au Injection

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Au (gold) is a heavy metal and its complexes are one of the more effective medicaments available for rheumatoid arthritis, although many authors have reported serious kidney damage during the chrysotherapy. In this article, the mechanisms of the DNA damage in renal kidney of rats after Au injection are reviewed. Cu content in the kidney of the Au-injected rat dramatically increased in comparison with Au and Zn content and that Cu-binding metallothionein (MT) was predominantly observed in the outer stripe of the outer medulla in the kidney. The signals of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) and the immunoreactivity of 8-hydroxydeoxyguanosine (8-OHdG) were located in the cortex of the Au-injected rat. Cu detected by Timm's method was mainly distributed in the cortex of Au-injected rat. These findings suggested that the oxidative DNA damage in the kidneys of rats injected with Au is associated with Cu of the cortex except Cu-MT. I postulate that the DNA cleavage might be caused by hydroxyl radicals formed by a monovalance of copper.

収録刊行物

  • Biomedical research on trace elements  

    Biomedical research on trace elements 18(1), 73-78, 2007-03-31 

    Japan Society for Biomedical Research on Trace Elements

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各種コード

  • NII論文ID(NAID)
    10018911079
  • NII書誌ID(NCID)
    AN10423256
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    0916717X
  • NDL 記事登録ID
    8769372
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z19-3255
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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