Enhanced Electrochemical Detection of Ketorolac Tromethamine at Polypyrrole Modified Glassy Carbon Electrode

• SANTHOSH Padmanabhan

  Department of Industrial Chemistry, Alagappa University

• SENTHIL KUMAR Nagarajan

  Department of Industrial Chemistry, Alagappa University

• RENUKADEVI Murugesan

  Department of Industrial Chemistry, Alagappa University

• GOPALAN Anantha Iyengar

  Department of Industrial Chemistry, Alagappa University

• VASUDEVAN Thiyagarajan

  Department of Industrial Chemistry, Alagappa University

• LEE Kwang-Pill

  Advanced Analytical Science and Nanomaterials Lab, Department of Chemistry Education, Kyungpook National University

Abstract

A glassy carbon electrode modified with a coating of polypyrrole (Ppy) exhibited an attractive performance for the detection and determination of a non-steroidal and non-narcotic analgesic compound, ketorolac tromethamine (KT). Cyclic voltammetry, differential pulse and square wave voltammetry were used in a combined way to identify the electrochemical characteristics and to optimize the conditions for detection. For calibrating and estimating KT, square-wave voltammetry was mainly used. The drug shows a well-defined peak at -1.40 V vs. Ag/AgCl in the acetate buffer (pH 5.5). The existence of Ppy on the surface of the electrode gives higher electrochemical active sites at the electrode for the detection of KT and preconcentrate KT by adsorption. The square-wave stripping voltammetric response depends on the excitation signal and the accumulation time. The calibration curve is linear in the range 1 × 10^-11 to 1 × 10^-7 M with a detection limit of 1.0 × 10^-12 M. Applicability to serum samples was also demonstrated. A detection limit of 1.0 ng ml for serum was observed. Square-wave voltammetry shows superior performance over UV spectroscopy and other techniques.

Journal

• Analytical Sciences

  Analytical Sciences 23 (4), 475-478, 2007

  The Japan Society for Analytical Chemistry

Keywords

• Analytical Chemistry

Details

• CRID: 1390001204256869632
• NII Article ID: 10018914445
• NII Book ID: AA10500785
• DOI: 10.2116/analsci.23.475
• ISSN: 13482246
• ISSN: 09106340
• NDL BIB ID: 8698642
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8698642
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.23.475.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.23.475/fulltext.html
• Web Site: http://www.jstage.jst.go.jp/article/analsci/23/4/23_4_475/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed