液体論でみるタンパク質の体積とその水和効果 Partial Molar Volume and Hydration of Proteins Studied by the Molecular Theory of Solvation

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著者

    • 今井 隆志 IMAI Takashi
    • 立命館大学情報理工学部 生命情報学科 Department of Bioscience and Bioinformatics, Ritsumeikan University

抄録

The partial molar volume (PMV) is the most fundamental thermodynamic quantity in considering the pressure effects on protein stability and function. The PMV is determined by the hydration as well as the geometry of the solute. However, it is difficult to extract the hydration effects from the PMV by the conventional methods. The 3D-RISM theory, which is a modern statistical-mechanical theory of molecular solvation, enables us to analyze the PMV in terms of hydration. In this article, recent applications of the 3D-RISM theory to some subjects concerning the PMV of protein are reviewed. The topics include the volume difference between low- and high-pressure structures, the volume change associated with the helix-coil transition, and the volume change accompanying ligand-protein binding.

収録刊行物

  • 高圧力の科学と技術 = The Review of high pressure science and technology  

    高圧力の科学と技術 = The Review of high pressure science and technology 17(1), 23-31, 2007-05-20 

    The Japan Society of High Pressure Science and Technology

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各種コード

  • NII論文ID(NAID)
    10018918347
  • NII書誌ID(NCID)
    AN10452913
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    0917639X
  • NDL 記事登録ID
    8742656
  • NDL 雑誌分類
    ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z17-1589
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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