高圧力をもちいたアミロイド線維研究の展開 Recent Applications of High Pressure to the Studies of Amyloid Fibrils

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Pressure is an important perturbant applied in studies of folding and unfolding of globular proteins. Recently, the application of this perturbant has been extended to the study of amyloid fibrils, which will be reviewed here. The effects of pressure on amyloid fibrils seem various, being positive or negative, dependent on the protein species and experimental conditions. Several reports have shown that pressure drives the formation of amyloid fibrils via pressure-induced unfolded structure of proteins. In contrast, there are also several studies showing the pressure-induced depolymerization of amyloid fibrils, suggesting the deficient packing and/or hydration in the fibril structure. Furthermore, a novel adaptation or maturation phenomenon has been found under pressurized conditions, demonstrating the structural diversity of amyloid fibrils, one of unique features which cannot be predicted with Anfinsen's dogma.

収録刊行物

  • 高圧力の科学と技術 = The Review of high pressure science and technology  

    高圧力の科学と技術 = The Review of high pressure science and technology 17(1), 42-49, 2007-05-20 

    The Japan Society of High Pressure Science and Technology

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各種コード

  • NII論文ID(NAID)
    10018918410
  • NII書誌ID(NCID)
    AN10452913
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    0917639X
  • NDL 記事登録ID
    8742686
  • NDL 雑誌分類
    ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z17-1589
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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