ぶどう膜炎, 白毛を伴った転移性悪性黒色腫の1例 A Case of Uveitis and Poliosis with Metastatic Malignant Melanoma
A 55-year-old woman presented with a subcutaneous tumor in her left inguinal region in 1998. An aspiration biopsy of the mass demonstrated tissue consistent with metastatic malignant melanoma. A surgical excision of the tumor was performed in 1999. An extensive search failed to identify the primary lesion. At the time of the initial tumor developement, the patient had poliosis of the scalp. Approximately 3 months after the developing the tumor, she noticed a visual disturbance in her right eye. Uveitis and optic neuritis were diagnosed, and the patient was followed up without any treatment. Vitiligo may thus be an immunologically mediated by melanocyte destruction. Circulating antibodies to the melanocytes have been found in some patient with vitiligo. Ocular abnormalities occurring in depigmented patients have been reported to be especially common when leukoderma is associated with cutaneous melanoma. Therefore, our present report suggests that the autoimmune system plays an important role in the occurence of poliosis and uveitis associated with malignant melanoma. In addition, the presence of hypopigmentation and uveitis has a positive influence on the prognosis of patients with malignant melanoma.
- 西日本皮膚科 = The Nishinihon journal of dermatology
西日本皮膚科 = The Nishinihon journal of dermatology 64(2), 203-206, 2002-04-01
Western Division of Japanese Dermatological Association