Angiosarcoma on the Right Cheek.

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  • 頬部血管肉腫の１例

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Abstract

A 73-year-old woman was referred to our department for an evaluation of an erythematous lesion with an induration on her right cheek. A histological examination revealed irregular and anastomosing vascular channels from the dermis to the subcutaneous tissue, consisting of aggregates of tumor cells with atypical oval or spindle nuclei and eosinophilic cytoplasm, indicative of angiosarcoma. The patient was treated with an intra-arterial injection of recombinant interleukin 2(rIL-2) and local radiotherapy, thus resulting in complete resolution of the lesion which was confirmed histopathologically. However, the angiosarcoma recurred, and the patient died after seventeen months of rIL-2 treatment. Autopsy revealed that although the tumor was localized in her right cheek, other metastatic regions were not detected, thus suggesting that the rIL-2 treatment prevented metastasis. Immunotherapy by an intra-arterial injection of rIL-2 has been considered to be a useful treatment for angiosarcoma, however, our experience has shown this to only be a temporary measure. Therefore, it is necessary to establish a more conservative treatment for patients with angiosarcoma.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 64 (6), 718-721, 2002

    Western Division of Japanese Dermatological Association

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