グアイフェネシン-ケタミン-キシラジン混合液による牛の完全静脈麻酔法 [in Japanese] Total Intravenous Anesthesia in Cows Using a Combination of Guaifenesin, Ketamine, and Xylazine [in Japanese]
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キシラジ-ケタミンで麻酔導入したホルスタイン種雌成牛9頭中3頭に0.2%ケタミン溶液 (対照群), 6頭に1%グアイフェネシン-0.2%ケタミン-0.005%キシラジン混合液 (GKX群) を持続点滴投与して60分間麻酔維持した. 麻酔終了後, GKX群の3頭に総キシラジン投与量1.0mg当たりアチパメゾール0.25mg, 対照群にトラゾリン1.0mg/kgを静脈内投与した. GKX群の総麻酔維持液投与量は対照群のほぼ半量であった. 両群ともに心拍数と動脈血圧は良好に維持されたが, 呼吸性アシドーシスと低酸素血症が認められた. 平均起立時間は対照群では30分, GKX群ではアチパメゾールを投与しない3頭で63分, 投与した3頭で9分であった.
Total intravenous anesthesia (TIVA) using 1% guaifenesin-0.2% ketamine-0.005% xylazine (GKX) was applied to 9 clinically healthy cows which were premedicated with 0.02mg/kg IV atropine followed by 0.05 mg/kg IV and 0.05mg/kg IM xylazine. Anesthesia was induced by 0.5mg/kg IV ketamine and maintained for 60min by continous intravenous injection of GKX in 6 cases after recumbent, while 0.2% ketamine was injected in 3 control cases. At the end of anesthesia, 3 cases anesthetized with GKX were intravenously injected with atipamezole at a dose of 0.25mg/mg of the total xylazine injected, and control cases were antagonized by 1.0mg/kg IV trazoline. The mean total consumption of TIVA solution was 4.6m<I>l</I>/kg/hr in the GKX group while 8.8m<I>l</I>/kg/hr in the control group. During anesthesia, the acceptable heart rate and arterial blood pressure were maintained, although respiratory acidosis and hypoxemia were observed in both groups. The mean standing-up times after anesthesia in the GKX group were 9 and 63min with and without atipamezole, respectively, while 30min in the control group.
- Journal of the Japan Veterinary Medical Association
Journal of the Japan Veterinary Medical Association 49(10), 709-713, 1996-10-20
Japan Veterinary Medical Association