Clinicopathological Observations of Fibrous Osteodystrophy in Hokkaido Native Horses

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  • 北海道和種馬にみられた線維性骨異栄養症の臨床病理学的観察
  • ホッカイドウ ワシュバ ニ ミラレタ センイセイ コツ イ エイヨウショウ

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Abstract

Two Hokkaido native horses for fattening showed fibrous osteodystrophy, characterized by bilaterally symmetrical enlargement of facial bones, low hardness of bone puncture, lameness or stiffness. Serum calcium levels lowered, while inorganic phosphorus and magnesium levels and activities of ALP3 were elevated with markedly high serum parathyroid hormone concentrations. Of two cases treated with Ca, one case showed excess serum calcitonin but the other did not. Serum 1, 25-(OH) 2 VD levels increased obviously though 25-OH-VD concentrations were normal findings. Pathological examination revealed excessive bone resorption by osteoclasts, proliferation of fibrous tissues in the maxilla and mandibula, and hyperplastic enlargement of the parathyroid. The cases were considered to be caused by nutritional hyperparathyroidism after supplying diets with low calcium and high ratio of phosphorus/calcium.

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