臍帯出血を主徴とする黒毛和種牛の出血性疾患 [in Japanese] Bleeding Disorder in Japanese Black Cattle with Umbilical Cord Bleeding as a Major Clinical Sign [in Japanese]
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南九州の黒毛和種牛に散発する出血牛のうち,Chediak-Higashi症候群(C-HS)や血友病様疾患では観察されない重篤な臍帯出血を示した33例について検討したところ,1発生状況,血統調査および試験交配の結果から,遺伝性疾患の可能性が高く,2大部分が臍帯出血や血腫による多量出血で死亡し,3止血スクリーニング検査では,血小板ADP凝集(中等度の低下)以外に異常を示さないことが判明した.本症はC-HSや第VIII因子の著減を示す血友病様疾患とは異なる遺伝性出血性疾患と推測された.Bleeding from umbilical cord stump, which had been a rare symptom in the Chediak-Higashi syndrome(C-HS) or hemophilia-like disease, has been found in 33 Japanese Black cattle in the South Kyusyu area, Japan. We found that 1) the disease could be inherited by the enzootic study, the pedigree analysis and the result of a test mating; 2) most of those affected animals died within an year due to umbilical cord bleeding or recurrent hemorrhage; 3) the results of screening tests had no prominent abnormalities except the moderately low ADP-induced platelet aggregation. According to the results above, the hemorrhagic disease characterized by umbilical bleeding was considered to be a new inherited bleeding disorder which is totally different from the C-HS and the hemophilia-like disease.
- Journal of the Japan Veterinary Medical Association
Journal of the Japan Veterinary Medical Association 49(4), 237-240, 1996-04-20