Pharmacokinetics of Enrofloxacin in Dogs

• KANEMAKI Nobuyuki

  School of Veterinary Medicine, Azabu University

• MATSUURA Kenji

  School of Veterinary Medicine, Azabu University

• YASHIRO Noriko

  バイエル (株) 動物用薬品事業部

• TAKASU Kazushige

  (財) 日本食品分析センター大阪支所

• USHIRODA Hisako

  (財) 日本食品分析センター大阪支所

Bibliographic Information

Other Title

• 犬におけるエンロフロキサシンの体内動態
• イヌ ニ オケル エンロフロキサシン ノ タイナイ ドウタイ

Abstract

The injectable or tableted enrofloxacin (ERFX, 5mg/kg) was administered to 3 adult dogs, and urine or s erum (only with tablet) levels and binding rate to serum protein in vitro were measured. The urinary levels a fter injection and tablet medications were the same, showing peak levels of 72.3 and 78.0 μg/ml at 0-6 h rs, with continued high levels of 8.5 and 12.1 μg/ml at 12-24 hrs after subcutaneous and oral administrati ons, respectively. After tablet administration, serum level reached a peak of 1.8 μg/ml at 1.3 hrs, declining la ter with a half-life of 3.0 hrs and the AUC_0-24 of 11.0 μg·hr/ml. The in vitro protein binding rate of ERFX w as 32.6%.

Journal

• Journal of the Japan Veterinary Medical Association

  Journal of the Japan Veterinary Medical Association 48 (12), 957-959, 1995

  Japan Veterinary Medical Association

Keywords

• dog
• enrofloxacin
• pharmacokinetics
• protein binding rate

Details

• CRID: 1390282679686116608
• NII Article ID: 10018942654
• NII Book ID: AN00191857
• DOI: 10.12935/jvma1951.48.957
• COI: 1:CAS:528:DyaK28XntFyrsQ%3D%3D
• ISSN: 21860211
• ISSN: 04466454
• NDL BIB ID: 3644181
• Web Site: https://agriknowledge.affrc.go.jp/RN/2030531348
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3644181
• Web Site: https://search.jamas.or.jp/link/ui/1996125265
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed