SPF猫にみられた腰痿例の病理組織学 [in Japanese] Histopathology of Lumber Paralysis in SPF Cats [in Japanese]
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後肢のふらつき, 起立困難, 痛覚消失などの腰痿症状を示したSPF猫6頭について病理組織学的に検索した. 病変は中枢神経に主座し, 脊髄白質では髄鞘の空胞化・膨化がみられ, アストロサイト, マクロファージの反応, 二次的な軸索崩壊などをともなっていた. 病変の分布および程度は, 腰髄, 胸髄で強く, 頸髄では比較的軽度であった. 病変の強さと腰痿症状のそれとは相関していた. 大脳白質では, 脂肪顆粒細胞の囲管性集簇とアストログリオーシスが認められ, 腰痿症状を示さなかった例で強く発現していた.
Six SPF cats showing "lumbar paralysis" with abnormal gait of the hind limb, and dysstasia without pain were studied histopathologically. In the central nervous system lesions were characterized by spongy changes of myelin sheaths with vacuoles of varying size accompanied with infiltration of macrophages and plump reactive astrocytes and occasionally with secondary axonal degenaration. Degeneration of the white matter was present throughout the length of the spinal cord, more severely in the thoracic and lumbar levels than in the cervical level. The severity of lesions was proportional to the degree of ataxic conditions. There were perivascular cuffing of fat granule cells and astrogliosis in the brain white matter, which appeared mainly in non-ataxic cases.
- Journal of the Japan Veterinary Medical Association
Journal of the Japan Veterinary Medical Association 48(9), 677-681, 1995-09-20
Japan Veterinary Medical Association