ブロイラー鶏における Clostridium perfringens による胆管肝炎の集団発生  [in Japanese] An Outbreak of Cholangiohepatitis due to Clostridium perfringens in Broiler Chickens  [in Japanese]

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Abstract

食鳥検査において51日齢ブロイラー (1農家1ロット) 2, 542羽中20羽 (0.79%) に胆管肝炎発生がみられた. 全部廃棄処分となった20例のほぼ全例で肝臓の腫大, 退色および小葉構造の明瞭化がみられ, 胆嚢の腫大と壁の肥厚あるいは肝外胆管の高度拡張を伴っていた. 病理組織学的には, グリソン鞘を中心とした細胆管の増生および線維化が著明で, 重度の例では肝細胞索が消失し, 肝細胞塊が島状に散在していた. 肝内胆管では胆汁溢出性および細菌性の多発性肉芽腫の形成がみられ, 肉芽腫の周囲にはリンパ球および形質細胞の浸潤が高度で胚中心形成が認められた. 肝内胆管, 肉芽腫, 胆嚢および肝外胆管に多数認められたグラム陽性大桿菌は, 蛍光抗体法により<I>Clostridium perfringens</I>抗原陽性で, <I>C.perfringens</I>が罹患鶏の肝臓から分離・同定された.

Twenty carcases of broiler chickens 51 days of age from a flock of 2, 542 birds were diagnosed as cholangiohepatitis at processing meat inspection. All affected cases showed enlargement and discoloration of liver with apparent acinar pattern. Enlarged gall bladder and extrahepatic bile ducts contained yellow inspissated material. Histopathologically, bile ductules were extensively proliferated with fibrosis forming interlobular bridges between triads. The portal bile ducts were destroyed and obstructed by multiple granulomas due to bacterial infection and the bile outflow. Infiltration of lymphocytes and plasma cells with germinal centers was also observed around granulomas. In these lesions many Gram-positive bacilli were observed and they were positive for <I>Clostridium perfringens</I> antigen by indirect immunofluorescence. <I>C. perfringens</I> was isolated and identified from affected livers.

Journal

  • Journal of the Japan Veterinary Medical Association  

    Journal of the Japan Veterinary Medical Association 51(9), 528-532, 1998-09-20 

    Japan Veterinary Medical Association

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Cited by:  1

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Codes

  • NII Article ID (NAID)
    10018948611
  • NII NACSIS-CAT ID (NCID)
    AN00191857
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    04466454
  • NDL Article ID
    4553914
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-352
  • Data Source
    CJP  CJPref  NDL  IR  J-STAGE 
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