ミンクアリューシャン病における肝内胆管の病理組織学  [in Japanese] Histopathology of Intrahepatic Bile Ducts in Minks with Aleutian Disease  [in Japanese]

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Abstract

臨床的にアリューシャン病 (AD) と診断された10例 (アリューシャン系9例, 非アリューシャン系1例) および健康なアリューシャン系1例のミンク (6~18カ月齢), 計11例の肝内胆管について, 病理組織学的に検討した. AD例の肝臓に共通して胆管増生と形質細胞増殖がみられたが, 増生胆管の上皮細胞は病理組織学的に正常肝内胆管に類似し, 免疫染色ではcytokeratin 18に陽性であった. しかし, AD例の増生胆管上皮細胞は抗ヒト癌胎児性抗原陽性を示し, 電子顕微鏡的には著しく変形して不規則な管腔を備える腺管構造を形成していた.

Intrahepatic bile ducts were histopathologically studied, in 6- to 18-month-old minks, with clinically diagnosed Aleutian disease (AD), (10 cases: 9 of Aleutian line and 1 of non-Aleutian line) as compared to one case without disease. The liver of AD-affected cases showed proliferation of bile ductules and plasma cells. Histopathologically, the proliferated epithelial cells were similar to those of normal bile ductules and positive for cytokeratin 18. Ultrastructurally, however, the tubular structure was markedly deformed with poorly differentiated lumen and the epithelium was positive for carcinoembryonic antigen.

Journal

  • Journal of the Japan Veterinary Medical Association  

    Journal of the Japan Veterinary Medical Association 51(8), 417-420, 1998-08-20 

    Japan Veterinary Medical Association

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Codes

  • NII Article ID (NAID)
    10018948675
  • NII NACSIS-CAT ID (NCID)
    AN00191857
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    04466454
  • NDL Article ID
    4536249
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-352
  • Data Source
    CJP  NDL  IR  J-STAGE 
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