A case of basaloid squamous cell carcinoma of the floor of the mouth-Estimation of proliferative activity by Ki-67 immunohistochemical staining-

• TSUNO Hiroaki

  Department of Oral and Maxillofacial Surgery, Toyama Medical and Pharmaceutical University

• WADA Shigehito

  Department of Oral and Maxillofacial Surgery, Toyama Medical and Pharmaceutical University

• TAKAZAKURA Takeshi

  Department of Oral and Maxillofacial Surgery, Toyama Medical and Pharmaceutical University

• INOUE Sayaka

  Department of Oral and Maxillofacial Surgery, Toyama Medical and Pharmaceutical University

• YAO Li

  Department of Oral and Maxillofacial Surgery, Toyama Medical and Pharmaceutical University

• FURUTA Isao

  Department of Oral and Maxillofacial Surgery, Toyama Medical and Pharmaceutical University

Bibliographic Information

Other Title

• 口底部に発生したｂａｓａｌｏｉｄ　ｓｑｕａｍｏｕｓ　ｃｅｌｌ　ｃａｒｃｉｎｏｍａの１例―Ｋｉ‐６７を用いた免疫組織化学的検索による細胞増殖能の評価―
• ショウレイ ホウコク コウテイブ ニ ハッセイ シタ basaloid squamous cell carcinoma ノ 1レイ Ki 67 オ モチイタ メンエキ ソシキ カガクテキ ケンサク ニ ヨル サイボウ ゾウショクノウ ノ ヒョウカ
• Estimation of proliferative activity by Ki-67 immunohistochemical staining
• Ki-67を用いた免疫組織化学的検索による細胞増殖能の評価

Abstract

Basaloid squamous cell carcinoma was first reported by Wain et al. in 1986 and has recently been designated a variant of squamous cell carcinoma because of its high potential for distant metastasis. We report a case of basaloid squamous cell carcinoma arising in the floor of the mouth in a 74-year-old man. The proliferative activities of this case and another case previously reported by our department were compared with those of 21 cases of poorly differentiated squamous cell carcinoma. The cases of basaloid squamous cell carcinoma showed high reactivity on Ki-67 immunohistochemical staining. This finding reflects the high malignancy of this disease and suggests that Ki-67 immunohistochemical staining is useful for diagnosis. Radiotherapy was very effective against the primary lesion in our two cases, but both had lung metastasis. In our patient, lung lesions were controlled by chemotherapy, but further investigations are needed to establish standard treatment, including systemic chemotherapy.

Journal

• Japanese Journal of Oral and Maxillofacial Surgery

  Japanese Journal of Oral and Maxillofacial Surgery 51 (12), 614-617, 2005

  Japanese Society of Oral and Maxillofacial Surgeons

Keywords

• basaloid squamous cell carcinoma
• radiotherapy
• metastasis

Details

• CRID: 1390001206531059072
• NII Article ID: 10018954120
• NII Book ID: AN00189163
• DOI: 10.5794/jjoms.51.614
• ISSN: 21861579
• ISSN: 00215163
• NDL BIB ID: 7785391
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7785391
• Web Site: https://search.jamas.or.jp/link/ui/2006092806
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed