口蓋に発生したｍｕｃｉｎｏｕｓ　ａｄｅｎｏｃａｒｃｉｎｏｍａの１例

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  • A case of mucinous adenocarcinoma arising in the palate
  • ショウレイ ホウコク コウガイ ニ ハッセイ シタ mucinous adenocarcinoma ノ 1レイ

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Mucinous adenocarcinoma is a rare malignant neoplasm included in the classification of salivary gland tumors by the WHO (1991). We report a case of mucinous adenocarcinoma arising in the hard palate. A 55-yearold man was referred to our hospital because of a painless swelling in the left side of the hard palate, which was first noticed about 2 months ago and had gradually increased in size. On initial examination, an elastic hard mass measuring approximately 7×6mm in diameter with indurations was palpable. Magnetic resonance imaging showed low signals on Tl-weighted images and high signals on T2-weighted images. An internal structure was mottled on T2-weigted images. The lesion was suspected to be a malignant salivary gland tumor on biopsy. The tumor was excised with left partial maxillectomy. Microscopically, the tumor was composed of nests, glands, and cords and had a cystic structure. Mucus-filled cystic cavities were lined by tumor cells, with some floating tumor cells. The tumor cells and cystic spaces were positive for mucicarmine and PAS. Immunohistochemically, pan-keratin, CK7, vimentin, and GFAP were positive in the tumor cells. The final histopathological diagnosis was mucinous adenocarcinoma.

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