急性骨髄性白血病患者の抜歯に際して顆粒球輸血を施行した1症例 Granulocyte transfusion administered to a patient with acute myeloid leukemia at tooth extraction
At present, granulocyte transfusions (GT) are used less and less frequently for infection control in patients with acute myeloid leukemia (AML). Application of GT is limited because of its low efficacy and potential adverse effects. It has been largely replaced by newly developed antibiotics and granulocyte colony stimulating (G-CSF) therapy. However, GT is considered useful in patients with serious infections caused by resistant bacteria or when G-CSF is ineffective. We describe our experience with GT in a patient with AML who underwent tooth extraction.<BR>A 42-year-old man with AML was referred because of a painful swelling in the left mandibular molar region. The clinical diagnosis was apical periodontitis of the second molar and pericoronitis of the third molar on the left side of the mandible. Since the patient did not respond to G-CSF, extraction of the second and third molars was perfomed along with GT. Postoperatively, graft versus host disease (GVHD) and infection did not develop, and the patient's course was uneventful.
日本口腔外科学会雑誌 51(11), 567-570, 2005-11-20
Japanese Society of Oral and Maxillofacial Surgeons